George Wythe Randolph was the twelfth child of Thomas Mann and Martha Jefferson Randolph. At the age of 13 he became a midshipman and served in the United States Navy. At 19, he went to the University of Virginia and later settled as a lawyer in Richmond, VA. He served as a Captain and then as a Brigadier General in the Confederate Army and was appointed as the Confederacy's Secretary of War in 1862 by Jefferson Davis. He died from a respiratory illness in 1867 at Edgehill, his father's estate and was buried in the Monticello graveyard.